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pentobarbital decreases levels of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can decrease panobinostat levels by ~70% and bring on therapy failure.pentobarbital will reduce the level or impact of osilodrostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism.Barbiturates are